Biophysics Services​

Evotec specializes in providing cutting edge biophysics services to support your drug discovery projects. Our state-of-the-art facilities allow access to the latest biophysics tools and technologies to deliver rapid, robust results. Our team of experts has a wealth of experience to guide strategy and help you to solve complex biological problems.

Biophysical readouts are elementary components alongside of target-based drug discovery and can be applied as primary and orthogonal assays. Backed by more than 15 years of experience in the field of biophysical screening Evotec has established a comprehensive biophysics platform supporting Hit Identification, Structural Biology, Protein Sciences and In Vitro Biology activities. The biophysics team will design the optimal experiment to meet the demands of recording of high-quality research data in a cost-efficient manner. This platform can deliver binding, structural and functional information or the kinetic profiling of target engagement for various modalities including small molecules, biologics or RNA-based approaches. Those data provide confidence about on-target activity of identified hit series and thus help focusing on the relevant chemical or biological samples for further progression.

Our biophysics platform includes the following techniques:

• Mass Spectrometry Services
  • Targeted MS approaches (RapidFire MS and Acoustic Ejection MS)
  • Affinity Selection MS
  • Intact MS and Native MS
  • Hydrogen-Deuterium Exchange MS
  • UPLC-MS and Quantitative UPLC-MS/MS
• Biosensor Services
  • Surface Plasmon Resonance (SPR)
  • Grating Coupled Interferometry (GCI)
• NMR-based Services
• Fragment-based Screening
• Orthogonal Technologies