Evotec offers fully integrated structural biology services tailored to support modern drug discovery. Our experts specialize in soluble and membrane proteins, biologics, protein-protein interactions, and protein-DNA/RNA complexes, as well as RNA molecules, which are increasingly important in novel therapies. With access to advanced techniques including X-ray crystallography, Cryo-electron microscopy (cryo-EM), and Nuclear magnetic resonance (NMR), we help clients determine high-resolution structures essential for structure-based drug design (SBDD) and therapeutic development.
Comprehensive Structural Biology Capabilities
Evotec delivers a full suite of multi-modality structural biology services to support drug discovery from early target validation to lead optimization. Our advanced techniques provide high-resolution insights into complex biological targets, enabling more informed and efficient therapeutic development:
X-ray Crystallography Services
High-resolution X-ray crystallography to support structure-based drug design (SBDD) and protein characterization
- Structural analysis of protein-ligand and nucleic acid-ligand complexes
- Novel protein and nucleic acid targets, including multi-component complexes
- Epitope mapping for antibodies, scFvs, VHHs, and TCRs
Cryo-EM Services
Advanced Cryo-electron microscopy (cryo-EM) for membrane proteins and complex biologics
- Structural determination of membrane protein-ligand complexes for SBDD
- Visualization of multi-component protein complexes, including viruses
Crystallographic Fragment Screening Services
High-throughput Crystallographic fragment screening to accelerate early-stage discovery
- Rapid identification of small-molecule binders
- Supports structure-guided optimization of leads
Conformational Dynamics & Biophysical Support
Analysis of conformational changes induced by ligands or environmental factors
- Investigations using BioSAXS
- Detailed profiling with HDX-Mass Spectrometry
Why Partner with Evotec
Scientists in drug discovery face persistent challenges—limited access to cryo-EM and synchrotron facilities, technical complexity in protein crystallization, and delays in producing high-resolution structural data. Many lack the internal capacity or integration needed to link structural analysis with functional outcomes. Evotec addresses these pain points through a unique combination of deep expertise, global infrastructure, and co-located teams in Molecular Design and Medicinal Chemistry, Biophysics, and in vitro Biology. Our ability to deliver structural insights into protein-ligand complexes, antibodies, and multi-component targets streamlines drug discovery workflows. We also support data collection, fragment screening, and the investigation of conformational changes, helping clients accelerate development and reduce risk. Evotec’s proven success in SBDD and biologics reflects our commitment to translating molecular insights into clinical progress.
