Antibody discovery

Antibody discovery 

Evotec maintains its own monoclonal antibody (mAb) research unit. Its growing discovery footprint is based on hybridoma technology leveraged to generate therapeutic mAb candidates. The unit deploys a breadth of workflows for immunisation, hybridoma generation and screening for binding and functional activity.

Antibody production

Protein production is a GLP-trained team able to produce mAbs in a short time and a wide range, from small scale (100 mg) to large-scale production (40 g), from hybridoma culture, transient transfection, or stable cell line culture after mAb gene synthesis and cloning. Volumes of culture are adapted to amount, from a few milliliters or liters (expression test, feasibility studies, and small-scale production) up to 100 liters (large-scale production).

Antibody purification is performed in two steps (affinity and polishing) to reach an optimal yield and high quality level, with high purity (≥ 99%), and low Endotoxin content for pre-clinical studies.

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