Biomarkers Enabling Precision Medicine Decisions Across Drug Discovery and Clinical Development

Evotec delivers integrated biomarker solutions that enable confident, data-driven decisions from early discovery through clinical development. By combining biomarker strategy design, advanced assay platforms, multi-omics technologies, and access to clinically relevant human samples, Evotec supports precision medicine across key therapeutic areas, including oncology, immuno-oncology, neuroscience, autoimmune diseases, and others. Biomarker activities are embedded across the drug discovery and development continuum to ensure alignment with therapeutic objectives and regulatory intent.

>20

Years experience in biomarker strategy design

>1,000

Assays developed annually

>60

Clients on an annual basis

>20

Years experience in biomarker strategy design

>1,000

Assays developed annually

>60

Clients on an annual basis

The applications below highlight how Evotec’s biomarker expertise is applied in practice, from early discovery to clinical development and trial support, ensuring biomarker data is translated into actionable insight across programs and platforms.

Evotec's Biomarker Expertise for Precision Medicine

Evotec’s tailored immunoassay services highlight the company’s leadership in advanced biomarker quantification, combining ultra-sensitive platforms like MSD®, SMCxPRO®, Quanterix® Simoa®, and NULISA™ to enable precise, compliant, and data-driven biomarker detection across discovery and clinical stages.

Tailored Immunoassay Services

Evotec combines state-of-the-art platforms such as MSD®, SMCxPRO®, Quanterix® Simoa®, and NULISA™ to achieve atto- to femtomolar sensitivity, enabling confident detection of low-abundance biomarkers.

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Evotec provides integrated histology solutions for biomarker discovery and translational research, combining tissue processing, multiplex immunohistochemistry, spatial analysis, and pathology expertise to support drug discovery and clinical development.

Biomarker Histology Solutions

Evotec's histology platform delivers end-to-end biomarker solutions from IHC to multiplex imaging for precision medicine in oncology and neuroscience.

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Evotec provides biomarker solutions for clinical trials, combining biomarker strategy design, GCP-compliant assay validation, and high-quality clinical sample analysis to support patient stratification, pharmacodynamic assessment, and regulatory-ready clinical development.

Biomarkers in Clinical Trials

Evotec offers GCP-validated biomarker analysis for clinical trials with AIFA-accreditation, end-to-end capability, and seamless IND to clinical trial transition.

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Evotec provides extracellular vesicle biomarker solutions for translational research and clinical development, combining vesicle isolation, characterization, and molecular analysis to support biomarker discovery, patient stratification, and precision medicine.

Exosome Biomarkers

Discover Evotec’s extracellular vesicle markers platform. Simultaneous RNA and protein analysis reveals elusive biomarkers.

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Evotec delivers biomarker strategy design to guide indication selection, patient stratification, and regulatory-ready clinical development, integrating translational science and validated assays.

Biomarker Strategy Design

Evotec’s Biomarker Strategy Design capability delivers translational, decision-driven biomarker plans aligned with mechanism of action, clinical positioning, and regulatory intent. By integrating scientific insight, human sample feasibility, and assay execution, Evotec helps de-risk development programs from early discovery through Phase I trials.

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Evotec provides integrated human sample management for biomarker-driven drug discovery and clinical development, combining compliant sample acquisition, clinical data access, and lifecycle management to support translational decision-making and precision medicine.

Human Sample Management

Evotec’s Human Sample Management platform enables compliant access to clinically annotated patient samples across discovery and clinical development. Integrated with translational biomarker workflows, the platform supports high-quality, fit-for-purpose human materials to accelerate biomarker discovery, validation, and clinical decision-making.

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Evotec provides integrated multi-omics services for biomarker discovery and translational research, combining genomics, transcriptomics, proteomics, and metabolomics to enable systems-level insights, patient stratification, and informed decision-making across drug discovery and early clinical development.

Multi-Omics Biomarker Solutions

Evotec's multi-omics services integrate genomics, proteomics, and metabolomics for biomarker discovery. From untargeted screening to GCP validation.

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Evotec provides integrated neuroscience / neurological biomarker solutions across drug discovery and early clinical development, combining biomarker strategy design, high-sensitivity assay platforms, and patient-derived samples to support target engagement, patient stratification, and translational decision-making in neuroscience programs.

Neuroscience Biomarkers

Evotec delivers end-to-end neuroscience/ neurological biomarker solutions for drug discovery: Multi-omics capabilities, ultra-sensitive detection, preclinical and GCP validation.

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Visual representation of Evotec’s oncology and immuno-oncology biomarker platforms showing integrated histology, multi-omics, and high-sensitivity assay technologies supporting precision oncology.

Oncology & Immuno-Oncology Biomarkers

Evotec supports oncology and immuno-oncology drug development through translational biomarker strategies that integrate patient-derived samples, high-sensitivity assays, and clinically relevant models. This approach enables target engagement assessment, patient stratification, and informed clinical decision-making across discovery and early clinical development.

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Precision Medicine

Precision medicine is a tailored approach to treatment and prevention that accounts for individual differences in genes, environment, and lifestyle. By aligning therapies with each patient’s biological profile, it enables accurate diagnoses, greater efficacy, and fewer side effects.

By integrating biomarker science, multi-omics tools, and patient-relevant models, precision medicine supports the creation of therapies matched to molecular disease features. This approach improves outcomes and reduces trial failures, expediting drug development and regulatory approval.

Evotec applies biomarkers to advance precision medicine by identifying patient subgroups most likely to benefit from targeted therapies, enabling predictive treatment selection and more effective drug development.

Figure 1. Role of precision medicine.

Driving Clinical Success Through Translational Biomarkers

Translational biomarkers play a central role in improving the efficiency and success of clinical development. By linking molecular insights to patient outcomes, biomarkers inform critical decisions across trial design, execution, and regulatory interaction. From identifying the right patients to optimizing development strategies and supporting regulatory confidence, biomarker-driven approaches enable more targeted, efficient, and predictable clinical programs.

Diverse Biomarkers Across Discovery & Clinical Development

Biomarkers are central to modern drug development, guiding decisions from disease detection to treatment response and enabling more targeted, efficient, and predictive development strategies across the clinical continuum.

Elizabeth van der Kam

Elizabeth van der Kam

SVP Global Translational Biomarkers

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Evotec has the right technologies & disease understanding to meet our partners' evolving needs: a comprehensive disease knowledge at the molecular level, cutting-edge technologies & platforms to translate this expertise into effective precision medicines.