X-ray Crystallography Services

Take advantage of Evotec’s 20 years of experience in X-ray crystallography. Our experienced scientists support both small-molecule drug discovery and biologics programs across diverse protein families. Using advanced construct design strategies, informed by a deep understanding of protein structure and its relationship to function, we reduce the number of constructs needed to establish successful crystal structures. Our team is fully integrated within Evotec’s structure-based drug discovery workflows, enabling rapid structure determination, improved insights into molecular interactions, and reduced design cycles.

Evotec offers versatile support across your structural biology workflow:

• From gene to structure, or at defined entry points tailored to your needs

• Expertise across diverse protein families, including integral membrane proteins, DNA/RNA-protein complexes, and multi-protein assemblies

• Support for the structure determination of RNA moieties and complex protein structures

• Engagements ranging from standard small-molecule-protein complexes to integrated drug discovery programs and focused epitope mapping studies

• Capabilities to generate novel structures, replicate literature-reported crystal systems, or onboard your existing in-house systems

Evotec’s Structural Biology team, in close collaboration with Protein Sciences and Biologics groups, has developed in-depth expertise in antibody crystallization and characterization:

• In-house expression of antibodies (or Fabs) and antigens, producing crystal-grade protein
• Generation of Fab and Fab’ fragments
• Structural resolution of epitope:paratope interfaces using X-ray crystallography or Cryo-EM
• Detailed interface analysis and in silico affinity maturation for antibody optimization