Background: Idiopathic nephrotic syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS cohort aims to facilitate novel ways of stratifying INS patients to improve disease understanding, therapeutics and design of clinical trials.

Methods: NURTuRE-INS is a prospective cohort study of children and adults with INS in a linked biorepository. All recruits had at least one sampling visit collecting serum, plasma, urine and blood for RNA and DNA extraction, frozen within 2 hours of collection. Clinical histology slides and biopsy tissue blocks were also collected.

Read the full publication for results and conclusions from the the NURTuRE-INS cohort study. 

_Affiliations

_{1 Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.}

_{2 MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.}

_{3 Centre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.}

_{4 Kidney Research UK, Peterborough, UK.}

_{5 Nephrotic Syndrome Trust, Somerset, UK.}

_{6 Experimental Renal Medicine, Medical School, University of Sheffield, Sheffield, UK.}

_{7 Metabolic Disease and Bioinformatics, Evotec International GmbH, Hamburg, Germany.}

_{8 Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.}

_{9 Division of Laboratory Medicine, Diagnostics Department and Department of Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.}

_{10 Leeds Institute of Medical Research at St James's, School of Medicine, University of Leeds, Leeds, UK (now Emerita position).}

_{11 UK Renal Registry, Bristol, UK.}

_{12 Department of Experimental Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK.}

_{13 Department of Paediatric Nephrology, Evelina London, Guy's and St Thomas' NHS Trust, London, UK.}

_{14 Department of Renal Medicine, Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.}