Crystallographic Fragment Screening

Increased throughput achieved by automation around crystal handling and diffraction data analysis has rendered Crystallographic Fragment Screening a much sought-after primary fragment screening technology. In comparison to conventional high-throughput screening methods, it provides immediate spatial information and thus instructs on relevance of the binding site and routes for rational downstream fragment elaboration.

Evotec's Crystallographic Fragment Screening Service Offering

  • Establishing high-resolution soakable crystal systems
  • Solvent tolerance testing to maximize fragment concentrations and minimize attrition
  • Access to Evotec’s proprietary library of 500 highly concentrated X-ray fragments and multiple libraries from Diamond Light Source
  • High-throughput crystal fragment soaking
  • Parallelized downstream data analysis
John Barker

John Barker

EVP Head of Global Protein Sciences

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Evotec has the right technologies & disease understanding to meet our partners' evolving needs: a comprehensive disease knowledge at the molecular level, cutting-edge technologies & platforms to translate this expertise into effective precision medicines.