Evotec provides expertise in retrieving structural information on proteins and RNAs in solution via small angle X-ray scattering (SAXS). This technique delivers low resolution information on the overall shape, size and structure of proteins, RNAs and their complexes.

• Requires neither crystals nor special sample labelling
• Not limited by molecular mass or flexibility of the studied molecule

Services offered by Evotec include:

• Probing conformational changes upon ligand binding or environmental factors (temperature and pH)
• Quality control of protein/RNA solutions (oligomeric state, aggregation)
• Investigation of structural flexibility, probing of complex stability or its formation
• Time-resolved studies (oligomeric state, complex formation, aggregation)
• Validation of existing protein/RNA crystal structures in solution
• Integrative structural modelling of RNA structures by employing SAXS and SHAPE-MaP data together with computational methods