Evotec provides expertise in retrieving structural information on proteins and RNAs in solution via small angle X-ray scattering (SAXS). This technique delivers low resolution information on the overall shape, size and structure of proteins, RNAs and their complexes.

  • Requires neither crystals nor special sample labelling
  • Not limited by molecular mass or flexibility of the studied molecule

Small Angle X-Ray Scattering (BIOSAXS)

Services offered by Evotec include:

  • Probing conformational changes upon ligand binding or environmental factors (temperature and pH)
  • Quality control of protein/RNA solutions (oligomeric state, aggregation)
  • Investigation of structural flexibility, probing of complex stability or its formation
  • Time-resolved studies (oligomeric state, complex formation, aggregation)
  • Validation of existing protein/RNA crystal structures in solution
  • Integrative structural modelling of RNA structures by employing SAXS and SHAPE-MaP data together with computational methods
Jay Bertrand

Jay Bertrand

VP Head of Global Structural Biology & Princeton Site Head

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Evotec has the right technologies & disease understanding to meet our partners' evolving needs: a comprehensive disease knowledge at the molecular level, cutting-edge technologies & platforms to translate this expertise into effective precision medicines.