Application of Design of Experiments in API Chemical Development

Biography

Francesco, a chemistry graduate from the University of Padova (Italy) in 1991, embarked on his career at Glaxo in Verona in 1992. Initially part of the Chemical Development Department, he honed his expertise in lab-scale chemistry and scale-up challenges. Later, as a member of the Lab Automation Team since 1997, Francesco developed and utilized automated systems for multiple and parallel reactions, enabling rapid optimization and deeper understanding of chemical processes. His profound knowledge of Quality by Design (QbD) principles and statistical tools, including principal component analysis (PCA), multivariate analysis (MVA), and experimental designs (DoE), seamlessly integrates with automated workstations for solvent/reagent screenings and process optimization. Currently, at Evotec Verona’s API Development and Manufacturing Department, Francesco oversees chemical projects from conception to pilot plant technology transfer, ensuring a smooth progression from route definition to reaction optimization.