Assessment of the physiochemical properties of antibodies enables identification of those that can successfully progress from discovery to development. Selection of the best candidates based on developability, as well as affinity and function, allows for maximal impact during the discovery phase.
Evotec offers flexible high-throughput early-stage developability packages to support candidate screening and characterization. In silico analysis of the sequence and predicted structure is used to identify sequence liabilities and hotspots, predict immunogenicity, and assess solubility and conformational stability.
Additional experimental workflows are offered to support lead candidate selection, including accelerated stress, forced degradation, and freeze/thaw studies, glycan profiling, and peptide mapping.
Evotec's Antibody Developability Services
- In silico property and structure analysis
- Multiparametric conformational stability analysis
- High-throughput physical chemical properties analysis
- Customized reporting service to support the best candidate selection
Antibody Developability Assessment Workflow
Why Evotec?
Superior Quality
A diligent team of antibody production experts and comprehensive quality control measures ensures Evotec delivers high-quality biologics that can be trusted for any downstream application.
Custom-Built Solutions
Evotec’s services can be tailored to your needs, whether that be producing hundreds of sequences in parallel or producing multiple grams and performing extensive characterization of lead molecules. Evotec implements go/no-go strategies for project de-risking.
Fast Turnaround Times
Optimized expression and purification platforms enable sequence-to-protein delivery of antibodies in as little as three weeks.
Cost-Effective Solutions
Evotec's proprietary technologies and dedicated workflows allow high-titer expression and rapid purification of antibodies, which enables very competitive pricing.
