In the race to develop safer, more effective therapies, physiological relevance of our platforms is of paramount importance. That’s why Evotec is championing the use of native cells in electrophysiological studies - a game-changer in the quest for more predictive and reliable preclinical data.

While recombinant systems have long been a staple in early-stage drug screening, they often fall short in replicating the intricate environment of living organisms. Native cells, by contrast, retain their natural cellular architecture, including the correct expression of ion channels, receptors, and proteins. This makes them an invaluable tool for:

• Physiological Relevance: Native cells mirror the true biological context, offering insights that are more reflective of in vivo conditions.
• Complex Interactions: They preserve the nuanced interplay between cellular components—interactions that are often lost in artificial systems.
• Predictive Accuracy: By bridging the gap between in vitro and in vivo models, native cells enhance the reliability of preclinical findings.
• Reduced Artifacts: Unlike recombinant systems, native cells express proteins at physiological levels, minimizing the risk of misleading data.

Evotec’s state-of-the-art electrophysiology platforms - ranging from manual and automated patch clamp to multi-electrode arrays (MEAs) - enable high-resolution analysis of electrical activity in a wide variety of native cells.

And the cell models? They’re as diverse as the diseases they help tackle in different therapeutic areas - Neurology, Cardiovascular, Respiratory, Inflammation & Immunology and many more:

• Rodent primary neuronal cultures (e.g., dorsal root ganglia, hippocampal, and cortical neurons)
• Human iPSC-derived neurons and neurospheres
• Human iPSC-derived cardiomyocytes
• Fresh human immune cells (T-lymphocytes)
• Human bronchial epithelial cells
• Fresh human sperm cells

This diversity allows Evotec to tailor studies to specific research needs, offering customized solutions that align with the unique challenges of each project.

Behind Evotec’s success is a multidisciplinary team of electrophysiologists whose combined academic and pharmaceutical experience fuels innovation. Their mission? To bridge the gap between cutting-edge research and real-world therapeutic applications.

By integrating native cell models into electrophysiological studies, Evotec is not just enhancing the quality of data - it's reshaping the future of drug development. Whether you're exploring ion channel pharmacology, neurodegenerative diseases, or immune cell modulation, Evotec offers the tools, talent, and technology to take your research further.