Thank you for requesting our article. Please find it available for download below.

Drug-induced liver injury (DILI) is a leading cause of drug failure due to poor translation between traditional preclinical animal models and human clinical outcome. More sophisticated human in vitro cell-based models with multiparametric endpoints are now being developed to improve DILI prediction.

In this review article, we focus on:

• the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery
• how companies are addressing translational challenges using human relevant cell-based models
• a further insight into the key role of human exposure and hepatic drug uptake transporters (e.g., OATPs, OAT2)