The cytochrome P450 enzyme, CYP46A1, is predominantly expressed in the brain and plays a major role in cholesterol metabolism by converting cholesterol to 24-hydroxy cholesterol.

In this poster, we focus on:

• The development and validation of an in vitro high throughput screening platform for characterisation of inhibitors and activators of CYP46A1
• A comparison of testosterone with cholesterol as a potential replacement probe substrate for studying CYP46A1 metabolism
• Data generated from a screening cascade of 2321 FDA approved drugs

Read our poster to learn more about our research!