SAR & Optimization of Proline-Based CB2 Receptor Agonists

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_{a Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877-0368, USA}

_{b Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach an der Riß, Germany}

_{c Evotec (UK) Ltd, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, United Kingdom}

_{d Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany}