Pharmacokinetic/pharmacodynamic (PK/PD) modelling plays an important role in drug development, especially in the case of antibiotics where the data generated is used for dose prediction up to Phase 2 clinical trials. This enables efficient study designs and identification of optimal dosing regimens that may suppress drug resistance.

In this poster, we focus on:

• Mathematical modelling of in vivo and in vitro data to generate a rational design with reduced animal requirements in order to determine the pharmacodynamic driver and magnitude of antibiotic efficacy
• Optimization of the clinical dose regimen in Phase 2 clinical trials

Read our poster to learn more about our research!

_{1 Cyprotex Discovery Ltd, No. 24 Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom}

_{2 Evotec, No. 23F Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom}