Mutant huntingtin (mHTT) protein has been implicated in neuronal degeneration in Huntington’s Disease.
In this publication, we focus on:
- A background to the inherited neurodegenerative disorder, Huntington’s Disease, including the impact of the mutant huntingtin (mHTT) gene
- A discussion of the use of positron emission tomography (PET) to monitor disease progression
- The identification of a novel ligand CHDI-626 which binds to mHTT aggregates
