Executive Summary

Evotec is a recognised leader in the field of HTS, combinatorial and medicinal chemistry and structural biology services to the pharmaceutical industry. An extensive range of capabilities in structural biology have been integrated within the company workflow to facilitate rapid delivery of structural data in support of drug discovery activities. Evotec appreciates the growing need for elucidation of membrane protein structures. Current membrane protein targets include GPCRs, channels and porins. The work is offered as an integrated package or as independent module for clients and for internal R&D activities. A platform for membrane protein structural biology has been established using GPCRs as a proof of concept. The workflow is illustrated below and outlines incorporation of key methodologies.