Our popular, easy-to-follow guide: ‘Mechanisms of Drug-induced Toxicity’ is available to read online.

Read about:

• An overview of the different mechanisms of toxicity including:
  • Mitochondrial toxicity
  • Reactive oxygen species (ROS) and oxidative stress
  • Reactive metabolite formation
  • Cell cycle mediated toxicity
  • Apoptosis
  • Genotoxic and non-genotoxic carcinogens
  • Phospholipidosis
  • Steatosis
  • Cholestasis
  • Cardiac ion channel effects and hypertrophy
• An assessment of the current in vitro methods available for determining mechanistic toxicology
• Key references and further reading related to the topic