In vitro 3D cell-based models are more representative of the complex in vivo microenvironment than traditional 2D monolayers. Furthermore, these models allow for long term compound exposures – more closely replicating clinical dosing strategies.

In this poster, we focus on:

• 3D human liver microtissues formed from multiple donors co-cultured with human non-parenchymal cells
• Exposure of the cells to multiple doses of hepatotoxins and non-hepatotoxins
• HCS analysis of DNA structure, GSH content, ROS formation and mitochondrial function
• The impact of correcting for therapeutically relevant tissue C_max

Read our poster to learn more about our research!