Domoic acid is a neurotoxin which was associated with the poisoning of 107 people and 3 subsequent deaths on Prince Edward Island in 1987 following the ingestion of mussels containing this poison. The associated neurotoxic effects of domoic acid are clearly identified at concentrations of ≥ 1µM using neurons analysed on a microelectrode array (MEA) platform. Interestingly, domoic acid had no effect up to 25µM in the neurite outgrowth assay (another common method for detecting neurotoxicity).

In this poster, we focus on:

• A comparison of the neurite outgrowth assay with the MEA platform
• Sensitivity of the two methods for detecting neurotoxins and seizurogenic compounds
• A screening strategy for testing neurotoxic compounds

Read our poster to learn more about our research!