This (Alternatives to Animal Experimentation) ALTEX paper by Uniliver demonstrates the application of New Approach Methodologies (NAMs) for regulatory safety evaluation of benzophenone-4, a commonly used UV filter in cosmetic products.

The research addresses a critical regulatory question about BP-4, which was included in a list of 28 potential endocrine disruptors in cosmetics requiring evaluation by the European Commission's Scientific Committee on Consumer Safety (SCCS). The study demonstrates how Next Generation Risk Assessment (NGRA) can effectively evaluate cosmetic ingredient safety while adhering to the EU's ban on animal testing for cosmetic ingredients implemented in 2013.

Cyprotex provided Cell Stress Panel (CSP testing) services and High-throughput transcriptomics (HTTr) sequencing capabilities, generating robust datasets with appropriate biological and technical replication. The work demonstrates practical implementation of NGRA principles within current regulatory frameworks.