Evotec’s High Throughput Experimentation (HTE) Platform in Drug Discovery and Development
High Throughput Experimentation (HTE) is a technology that enables conducting numerous experiments in parallel, as opposed to the traditional single-experiment approach.
By rationally designing parallel reactions, specific challenges can be addressed, and development conditions can be optimized. This can be achieved using various apparatus, with or without automation, allowing for the rapid screening of a wide array of reaction conditions in a short period, while requiring only minimal material.
At Evotec, we have implemented an HTE platform to develop and adapt several screening templates to quickly meet project requirements. This technology plays a critical role in both drug discovery and development, enabling us to gather large amounts of data rapidly while using minimal quantities of valuable materials.
Overview Of Contents
What is HTE?
Evotec’s HTE Breakthrough
- Advantages
What does Evotec use HTE for?
Our Four Case Studies
- HTE used to optimize a Suzuki coupling
- Enabling reaction with limited amount of material – Ullmann chemistry
- Challenging boron reduction
- Enabling building block synthesis to speed up Discovery project – Buchwald coupling
Complementary capabilities and HTE applications
Conclusions
The Future
