• Evotec receives undisclosed payment
• Evotec to continue supporting the collaboration through its unique integrated, accelerated IND-enabling platform to progress the program toward IND

Hamburg, Germany, 16 October 2025:
Evotec SE (Frankfurt Stock Exchange: EVT, SDAX/TecDAX, ISIN: DE0005664809; NASDAQ: EVO) today announced that Esperion Therapeutics (“Esperion”) (NASDAQ: ESPR) has nominated an oral preclinical development candidate for the treatment of primary sclerosing cholangitis (“PSC”), a major milestone stemming from the productive collaboration between Evotec and Esperion.

The collaboration between Evotec and Esperion explores new therapeutic opportunities in ATP citrate lyase (“ACLY”) biology, with the goal to develop next-generation inhibitors optimized to address multiple life-threatening diseases. This PDC was discovered leveraging Evotec’s fully integrated small molecule drug discovery and development platform together with Esperion’s deep expertise in ACLY biology. Evotec will continue to support the project with its unique integrated, accelerated IND-enabling platform (Evotec INDiGO) to progress the program toward IND. The PDC nomination triggered an undisclosed payment to Evotec.

Dr Cord Dohrmann, Chief Scientific Officer of Evotec, commented: “The nomination of this preclinical development candidate marks a major milestone in our joint approach, combining deep scientific expertise with seamless operational execution. It is a key step toward clinical development and highlights the strength and efficiency of our collaboration. We are proud to contribute to the advancement of a program that has the potential to address a critical gap in current treatment options.”

About Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis (“PSC”) is a rare, progressive, cholestatic, immune‐mediated disease of the bile ducts. Bile ducts carry the digestive liquid bile from the liver to the small intestine. In PSC, inflammation and injury cause scarring, stricturing, and concentric, obliterative fibrosis within the bile ducts. These processes make the bile ducts hard and narrow leading to biliary cirrhosis, portal hypertension, and eventually hepatic failure in a majority of patients.

The pathogenesis of PSC remains unknown and there is no proven medical or interventional therapy to halt the progression of disease. A liver transplant is the only known long-term treatment option for PSC, however up to 30% of patients who receive a liver transplant for PSC experience recurrence.

About Esperion Therapeutics
Esperion Therapeutics, Inc. is a commercial stage biopharmaceutical company focused on bringing new medicines to market that address unmet needs of patients and healthcare professionals. The Company developed and is commercializing the only U.S. Food and Drug Administration (FDA) approved oral, once-daily, non-statin medicines for patients who are at risk for cardiovascular disease and are struggling with elevated low density lipoprotein cholesterol (LDL-C). These medications are supported by the nearly 14,000 patient CLEAR Cardiovascular Outcomes Trial. Esperion continues to build on its success with its next generation program which is focused on developing ATP citrate lyase inhibitors (ACLYi). New insights into the structure and function of ACLYi fully enables rational drug design and the opportunity to develop highly potent and specific inhibitors with allosteric mechanisms.

Esperion continues to evolve into a leading global biopharmaceutical company through commercial execution, international partnerships and collaborations and advancement of its pre-clinical pipeline. For more information, visit esperion.com and follow Esperion on LinkedIn and X.

About Evotec SE
Evotec is a life science company that is pioneering the future of drug discovery and development. By integrating breakthrough science with AI-driven innovation and advanced technologies, we accelerate the journey from concept to cure — faster, smarter, and with greater precision.

Our expertise spans small molecules, biologics, cell therapies and associated modalities, supported by proprietary platforms such as Molecular Patient Databases, PanOmics and iPSC-based disease modeling.

With flexible partnering models tailored to our customers’ needs, we work with all Top 20 Pharma companies, over 800 biotechs, academic institutions, and healthcare stakeholders. Our offerings range from standalone services to fully integrated R&D programs and long-term strategic partnerships, combining scientific excellence with operational agility.

Through Just – Evotec Biologics, we redefine biologics development and manufacturing to improve accessibility and affordability.

With a strong portfolio of over 100 proprietary R&D assets, most of them being co-owned, we focus on key therapeutic areas including oncology, cardiovascular and metabolic diseases, neurology, and immunology.

Evotec’s global team of more than 4,800 experts operates from sites in Europe and the U.S., offering complementary technologies and services as synergistic centers of excellence. Learn more at www.evotec.com and follow us on LinkedIn and X/Twitter @Evotec.

Forward-looking statements
This announcement contains forward-looking statements concerning future events, including the proposed offering and listing of Evotec’s securities. Words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “should,” “target,” “would” and variations of such words and similar expressions are intended to identify forward-looking statements. Such statements include comments regarding Evotec’s expectations for revenues, Group EBITDA and unpartnered R&D expenses. These forward-looking statements are based on the information available to, and the expectations and assumptions deemed reasonable by Evotec at the time these statements were made. No assurance can be given that such expectations will prove to have been correct. These statements involve known and unknown risks and are based upon a number of assumptions and estimates, which are inherently subject to significant uncertainties and contingencies, many of which are beyond the control of Evotec. Evotec expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Evotec’s expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based.