Join us in Berlin at the European Crohn's and Colitis Organization Congress. Learn more about our involvement in the event below.
Evotec At ECCO
Modeling Inflammatory Bowel Disease in Mice with “Humanized” Immune System
Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease with unknown etiology. Dextran sulfate sodium (DSS) induced colitis is a common preclinical mouse model in IBD research. DSS colitis involves activation of the submucosal immune system and can be used to study Ulcerative Colitis characteristics in different phases (acute, chronic and remission) and predict compound efficacy. However, optimizing translation to human is still needed and the use of mice with Human Immune System (HIS) provide a better model to study human immune system responses in vivo. HIS mice are created by transplanting human immune cells or their progenitor cells into highly immunodeficient recipient mouse hosts, thereby "humanizing" their immune systems. In this study we discussed colitis feature and the use of humanized mice model for testing therapeutics in preclinical studies.
Date: Friday, February 21, 2025
Time: 12:40 - 13:40
Session Name: Guided Poster Session
Session Hall: Poster Exhibition, Hall 2.2
Presented by Berengere Coupe, Deputy TA lead Gastrointestinal Diseases, Senior Research Scientist, Immunology & Inflammation
