Join us in Palm Springs, CA at CHDI's 21st Annual Huntington's Disease Therapeutics Conference (HDTC). Learn more about our involvement in the event below.
Evotec at HDTC 2026
Poster Presentations
Date and Time: Wednesday, 25 February 2026, from 1:00 pm - 4:00pm PST
- Allosteric pocket identification and validation in the MutSβ connector domain through combined in silico modeling and experimental studies
- Ultra-large library virtual screening and multi-assay validation of MutSβ allosteric pocket binders
- Narrowing the CAG Window: An iPSC-Based Platform to Study Somatic Repeat Expansion in Post-Mitotic Neurons
- URSA: Un-scheduled DNA Repair Synthesis Assay for fast Somatic Instability (SI) measurement
- Exploratory analysis of PENK and PDYN as early markers of HD onset and progression
- CSF and Plasma Extracellular Vesicle Proteins as Potential Biomarkers in Huntington’s Disease
- Probing HTT RNA by SHAPE to enable allele-selective targeting with small molecules
- Downregulation of HTT species by CAG-binding ZFPs
- A Dual Assay Cellular Platform to Characterize Pharmacological and Genetic Modulation of MMR Activity and CAG Somatic Instability in Huntington’s Disease
- A novel FLIPR-based high-throughput assay for parallel detection of MutSβ interaction with CAG loop DNA and MutSβ ATPase activity.
- Small molecule inhibitors of MutSbeta ATPase and DNA binding activity halt CAG expansion at the HTT locus in human pluripotent stem cell models.
