Assessment of Neuronal Activity Using Microelectrode Array:

  • The eCiphr®Neuro assay uses primary cultures of rat cortical neurons.
  • Cyprotex’s neuronal assay uses high throughput microelectrode array (MEA) technology to monitor electrophysiological activity.
  • Neurons grown on microelectrode arrays recapitulate many features of neurons in vivo, including spontaneous activity (spiking and bursting), plasticity, organisation and responsiveness to a wide range of neurotransmitters and pharmacological agonists/antagonists1.
  • This technology provides a unique in vitro system for preclinical drug discovery, neurotoxicity assessment and disease modelling.


eCiphr®Neuro Assay Protocol


Data from Cyprotex's eCiphr®Neuro Assay


1) Robinette BL et al, (2011) Front Neuroeng 4; Article 1
2) Margineau DG and Wülfert E (1997) Br J Pharmacol 122; 1146-1150
3) Mackenzie L et al, (2002) Clin Neurophysiol 113(4); 586-596
4) Ono J et al, (1990) Funct Neurol 5(4); 345-352
5) Fuentealba J et al, (2011) Neuropharmacology 60; 453-459
6) Levy LM and Degnan AJ, (2013) Am J Neuroradiol 34(2); 259-265
7) Hwang DF and Noguchi T (2007) Adv Food Nutr Res 52; 141-236
8) Peña F and Tapia R (2000) Neuroscience 101(3); 547-561
9) Pulido OM (2008) Mar Drugs 6(2); 180-219
10) Hankir MK et al, (2012) Neuroimage 59(2); 968-978
11) Kehne JH et al, (1992) Br J Pharmacol 106(4); 910-916


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Paul Walker

Paul Walker, PhD

VP Head of Toxicology & Innovation Efficiency

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Cyprotex enables and enhances the prediction of human exposure, clinical efficacy and toxicological outcome of a drug or chemical. By combining quality data from robust in vitro methods with contemporary in silico technology, we add value, context and relevance to the ADME-Tox data supplied to our partners in the pharmaceutical or chemical industries.