Mitochondrial Toxicity

Mitochondrial Oxidative Stress Assay

Introduction

  • Mitochondria consume the majority of cellular oxygen and regulate redox-signalling1.
  • Toxic drugs can induce mitochondrial reactive oxygen species (mROS) causing mitochondrial/cellular damage which has been linked to the pathology of many diseases2.
  • The Cyprotex mitochondrial oxidative stress assay detects selective mROS production caused by the toxicity of novel compounds.

Protocol

Mitochondrial Oxidative Stress Assay Protocol

Data

Data from Cyprotex's Mitochondrial Oxidative Stress Assay

References

1) Zorov DB et al., (2014) Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release. Physiol Rev 94(3); 909-950
2) Ježek P et al., (2020) Redox Signaling from Mitochondria: Signal Propagation and its Targets. Biomolecules 10(1); 93

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Julie Eakins

Julie Eakins

Associate Principal Scientist

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Cyprotex enables and enhances the prediction of human exposure, clinical efficacy and toxicological outcome of a drug or chemical. By combining quality data from robust in vitro methods with contemporary in silico technology, we add value, context and relevance to the ADME-Tox data supplied to our partners in the pharmaceutical or chemical industries.