ADME (Absorption, Distribution, Metabolism, Excretion) and toxicology studies are an essential component in drug development, providing insights into how drugs are absorbed, distributed, metabolized, and eliminated in the body, while also assessing their potential toxicity. These studies help optimize drug formulations, identify potential risks, and ensure the safety and efficacy of medications for patients.

We can help you identify which compounds have the optimal ADME profile to advance into the clinic. Our experience extends from early discovery through to the clinic so we have a full picture of the entire drug discovery and development continuum and can support you at every stage of your project. Our scientific expertise and capabilities can be accessed as fee-for-services or as part of partially or fully integrated programs.

ADME, Drug Metabolism & Pharmacokinetic Services

ADME studies can be used to estimate the plasma and tissue concentrations in the body (pharmacokinetics). There is a clear link between pharmacokinetics/tissue exposure and clinical efficacy and safety due to either on-target or off-target effects.

We offer a comprehensive and flexible range of in vitro and in vivo DMPK/ADME studies designed to cover from hit-to-lead and lead optimization phase through candidate selection and to the clinic . We also offer in vitro metabolite profiling, structural elucidation and DDI (drug-drug interaction) studies for IND and NDA submissions during preclinical development and clinical stage projects.


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