About the Webinar

The field of Immune Cell Engagers (ICEs) — including bispecific and multispecific biologics — is rapidly advancing and redefining cancer therapy. By redirecting T cells, NK cells, and myeloid cells to identify and kill tumor cells, ICEs are unlocking new possibilities in Immuno-Oncology.

While ICEs have primarily been applied to hematological malignancies, the recent FDA approval of the first ICE for solid tumors marks a major milestone. Yet, discovering and optimizing new ICEs remains complex, requiring deeper insights into cellular mechanisms.

At Evotec, we believe that progress lies in understanding the Immunological Synapse — the dynamic interface where immune cells communicate with target cells. Our cutting-edge imaging and single-cell analysis platforms allow researchers to:

Watch this webinar to:

  • Learn about immunological synapse: what it is and its functions in immune responses
  • Discover how the use of immunological synapse can be instrumental for drug discovery of immunotherapies
  • Hear how studying the immunological synapse can benefit the discovery of immune cell engagers and immune cell therapy

Meet Our Speaker

Michael Esquerre
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Michael Esquerré

VP Immuno-Oncology, In vitro Biology, Therapeutic Area Lead Immuno-Oncology

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Latest update: April 2025

Biography

Michael is a T-cell Immunologist with over 20 years of experience in the field, including 16 years in the cancer immunotherapy industry. Throughout his career, he has contributed to the development of cancer immunotherapeutics, progressing from R&D stages to Phase II clinical trials, with a focus on overseeing patient immunomonitoring strategies. For the past nine years, Michael has served as Vice President of Immuno-Oncology at Evotec, leading the Immuno-Oncology therapeutic area. Since 2019, he has been a member of the Cell Therapy core team, supporting the immunological characterization of iPSC-based immune cell therapies. In 2021, he was appointed Review Editor for T-cell Biology at Frontiers in Immunology. Michael's scientific career has been driven by a deep interest in understanding the biological mechanisms of immune response modulation and applying this knowledge to develop innovative cancer therapeutics. He has also contributed to numerous projects involving diverse therapeutic modalities, guiding them from early discovery to IND submissions and clinical trials. His work includes designing and overseeing biomarker strategies to monitor immune responses in patients, validating preclinical data, and supporting the clinical development of therapeutic candidate.

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