Evotec and the Jain Foundation announce extension of research collaboration in skeletal muscular dystrophy diseases


Hamburg, Germany - 21 August 2013: Evotec AG (Frankfurt Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) and the Jain Foundation today announced that they have extended and expanded their research collaboration leveraging Evotec's assay development and screening capabilities to support the Jain Foundation's goals of understanding and curing dysferlinopathy.

Dr Mario Polywka, Chief Operating Officer of Evotec, commented: 'We look forward to our continued collaboration with the Jain Foundation on this project. This collaboration highlights both the increasing role that foundations play in delivering solutions for unmet medical needs and also how Evotec's broad and comprehensive discovery platform can be leveraged in support of these goals in a highly efficient and effective manner.'

Dr Plavi Mittal, President and CEO of the Jain Foundation added: 'We are excited to be moving toward screening compound libraries with Evotec. This is an important step toward accomplishing our mission of finding a therapy for Limb-girdle muscular dystrophy type 2B /Miyoshi Myopathy (LGMD2B/MM).'

No financial details were disclosed. 


In 2012, Evotec and the Jain foundation initiated a research project to develop a cell-based high throughput screening assay using dysferlin deficient cells. The aim of this project is to develop a simple test for the well-being of a muscle cell in the absence of dysferlin so that compounds that improve the well-being of dysferlin deficient muscle cells can be identified.


The Jain Foundation, located in Seattle Washington, USA, is a privately funded not-for-profit focused on finding a therapy for muscular dystrophies caused by dysferlin deficiency(LGMD2B/Miyoshi Myopathy).


Muscular dystrophy refers to a group of diseases that produce muscle weakness. Muscular dystrophies all involve abnormalities of the muscle cells themselves, rather than the nerves that control the muscles. All muscular dystrophies are caused by genetic mutations.

Limb-girdle muscular dystrophy refers to a group of diseases (not a single disease) which were lumped together, long before the era of molecular biology and genetic engineering, because they shared some common clinical symptoms. The name refers to the first muscles to show symptoms, which are those around the shoulders and the hips.

Myopathy simply means 'muscle disease.' Miyoshi Myopathy (MM) is a form of muscular dystrophy that was first described in the medical literature by Miyoshi in 1967. Although first identified in Japan, it occurs worldwide. Miyoshi is caused by defects in the gene for the protein dysferlin.

Dysferlin is a protein made from the dysferlin gene that, when mutated or absent, causes both Limb-Girdle Muscular Dystrophy type 2B and Miyoshi Myopathy.


Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgement of Evotec as of the date of this report. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change
in events, conditions or circumstances on which any such statement is based.