Metabolic diseases and complications

 

Evotec has over 15 years of experience in metabolic disease drug discovery, starting from target identification up to pre-clinical development. Through internal and collaborative efforts we have built a highly sophisticated and integrated drug discovery platform.

  • Extensive expertise in metabolic disorders such as diabetes, obesity, metabolic syndrome, kidney disease, liver disease, and muscular dystrophy
  • A comprehensive portfolio of in vitro assays and in vivo models is in place to support drug discovery projects
  • Target tissues include pancreatic islets, skeletal muscle, kidney, adipose tissue and liver

Key capabilities of Evotec’s metabolic diseases discovery platform

Target identification and validation

Focus on identifying novel mechanisms and targets that have the potential to deliver drug candidates that prevent disease or even revert disease progression.

In vitro pharmacology

  •  High-content cellular analysis applied to phenotypic screens for new target classes in diabetes, obesity, chronic kidney & liver disease and muscle disease
  • Assay development for both screening and validation

Human podocytes stained with phalloidin

  • Established cell lines and primary cells such as beta cells, adipocytes, myocytes, hepatocytes and podocytes
  • Ex vivo primary islet, glomeruli, liver slices, and muscle preparations from animals and humans for compound profiling in physiologically relevant environments
  • Viral genetic modification for mechanism of action studies and target validation in vitro and in vivo

In vivo pharmacology

  • A variety of type 2 and type 1 diabetes models
  • Models of Diet Induced Obesity (DIO) as well as genetic models of obesity, diabetes, and associated complications, e.g. liver disease, retinopathy and diabetic nephropathy
  • Diet-induced NASH models
  • Strong focus on acute and chronic kidney disease in particular with respect to fibrosis
  • PK, PK/PD, mode of action studies, efficacy screening and in vivo pharmacology profiling
  • In vivo pre-clinical imaging: comprehensive set of morphometry and histology solutions

Evotec´s in-house capabilities include high-throughput screening, structure-based drug design, medicinal chemistry, bioinformatics research, DMPK, biomarker and reagent production platforms. Technology platforms include high-content imaging, transcriptomics, proteomics, energy metabolism in real time, and electrophysiology. These can be accessed to support and progress metabolic diseases drug discovery programmes.

Summary

  • The cornerstone of Evotec’s in vitro and in vivo pharmacology function is disease and target biology expertise coupled with state-of-the-art technology platforms
  • Comprehensive in vitro pharmacology platform covering islet, kidney, muscle, hepatic, intestinal and adipose tissue-based mechanisms
  • Highly developed, primary cell-based platform combined with a broad range of in vitro and in vivo models
  • Highly experienced in vivo group with state-of-the-art metabolic phenotyping, and histology with automated and quantitative image analysis

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Drug discovery services In vitro biology for metabolic diseases and complications In vivo pharmacology for metabolic diseases and complications EVT Innovate

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