Immunology & Inflammation

 

Evotec has developed substantial expertise in the immunology and inflammation fields and has built through collaborations and partnerships a state-of-the-art integrated drug discovery platform covering all aspects from target identification to investigational new drug (“IND”).

Our experienced immunology & inflammation team with over 30 scientists has an established and proven track record and has contributed to the discovery and development of multiple pre-clinical and clinical candidates in the area of inflammation, autoimmune disorders, pain and endometriosis.

Evotec’s core expertise in small molecule drug discovery in immunology and inflammation is complemented by a growing state-of-the-art know-how in the development of therapeutic antibodies.

Key capabilities of Evotec’s immunology & inflammation discovery platform

Phenotypic screening

  • Access complex cellular environments and use of primary cells and tissues
  • Assay platform routinely used to support both HTS and H2L/LO programmes for functional read-outs of lymphocytes, monocytes or other target cell types
  • Integrated into Evotec’s MS-based proteomic platform to aid target identification

In vitro pharmacology

  • Portfolio of relevant in vitro models for multiple target classes including ion channels, kinases, transporters, cytokine PPI, GPCRs, enzymes and pattern recognition receptors
  • Development and validation of novel customised assays for screening, validation and drug development
  • World-class ion channel electrophysiology platforms to successfully drive H2L, LO and safety pharmacology projects with high-quality and expedite turnaround times 

Rat (Sprague-Dawley)

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Lung: Penumonia, fibrinonecrotising, severe, diffuse, subacute

In vivo pharmacology

  • Pharmacodynamic assays (PK/PD ) including: IL-1b/desArg9 Bradykinin paw oedema, a,b-me-ATP flinching, (R)-a-methylhistamine induced dipsogenia, anti-CD3 T-cell activation/expansion, LPS cytokine release, plus a range of bespoke project-specific animal models
  • Portfolio of validated, disease relevant in vivo models in inflammation, neuro-inflammation, inflammatory pain, rheumatoid arthritis, osteoarthritis, psoriasis and anaemia
  • Animal models supported by ex vivo and translational read-outs to drive key project decisions in a timely manner, including flow cytometry/FACS

Additional capabilities such as Evotec’s high-throughput screening, structure-based drug design, medicinal chemistry, bioinformatics research, DMPK, proteomics and biomarker discovery and reagent production platforms can also be accessed to support and accelerate immunology and inflammation programmes.

Summary

  • Large tool kit of functional and translational assays using primary human lymphocytes and monocytes or whole blood assays
  • Expertise in many different target classes including enzymes, kinases, GPCRS, ion channels and PPI
  • Highly validated disease models in inflammation, neuro-inflammation, inflammatory pain, psoriasis and anaemia
  • Animal models supported by ex vivo and translational read-outs to drive key project decisions in a timely manner

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Drug discovery services In vitro biology for inflammation and immunology In vivo pharmacology for inflammation and immunology EVT Innovate

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