Evotec is one of the global leaders in providing complete drug discovery solutions on a stand-alone basis or through holistic, fully integrated drug discovery solutions. In EVT Execute, these services are provided on a typical fee-for-service basis or through a variety of commercial structures including research fees, milestones and/or royalties.
Our EVT Execute alliances are distributed all along the pre-clinical drug discovery value chain, covering a broad range of disease areas including anti-infectives, diabetes and diabetic complications, inflammation and immunology, neuroscience, oncology and pain.
Bayer - Endometriosis and chronic cough
In October 2012, Evotec and Bayer Pharma AG entered into a five-year, multi-target collaboration with the goal of developing three clinical candidates for the treatment of endometriosis. Both parties contribute innovative drug targets and high-quality technology infrastructures and share the responsibility for early research and pre-clinical characterisation of potential clinical candidates in the disease area of endometriosis.
Bayer will be responsible for any subsequent clinical development and commercialisation. Evotec will receive € 12 m as an upfront payment. In total Evotec may receive pre-clinical, clinical and sales milestones of potentially up to approximately € 580 m plus potential royalties of up to low double-digit percent of net sales.
The alliance has already generated multiple pre-clinical development candidates and the first programme progressed into Phase I clinical trials in August 2016. Two more Phase I studies were started in July 2017, and in April 2018. The alliance was extended for another year in 2017.
Phase II development in chronic cough
In July 2018, Evotec announced that a compound developed under the multi-target alliance with Bayer in the field of endometriosis was advanced into Phase II testing for treatment of chronic cough (BAY1817080). In February 2019, Bayer advanced another promising small molecule into Phase II clinical development for the treatment of persistent chronic cough.
In July 2019, positive Phase II results were published for BAY1817080.
To promote complementary inter-company cooperation for future research collaborations, Evotec and Bayer have published a white paper on their successful alliance.
Endometriosis affects an estimated 176 million women worldwide or 10% of women of reproductive age. It is caused by the abnormal growth of tissue similar to that which lines the uterus (endometrial tissue) in locations outside of the uterine cavity, where it causes ectopic lesion growth and debilitating pain. Endometrial growth is commonly found on the ovaries and pelvic peritoneum, potentially involving other organs of the pelvic cavity as e.g. bladder, bowel, and the rectovaginal space. There is no known cure for endometriosis and most available drug treatments have certain limitations. Endometriosis is a highly complex and heterogeneous disease and there is still a high unmet medical need for innovative therapies which address the individual needs of affected women. The disease can greatly impact a woman‘s social, professional and personal life, and women with endometriosis often experience a higher incidence of depression and emotional distress due to the uncertainty of diagnosis, unpredictability of symptoms and living a normal life.
CHDI - Huntington
CHDI Inc., a not-for-profit organisation pursuing a biotech approach to finding therapies for Huntington’s disease, has chosen Evotec as a strategic partner for helping them advance its drug discovery programmes.
Since March 2006, Evotec and CHDI have a number of agreements covering integrated biology and chemistry supported by compound and library management, target validation, stem cell research, high-content screening, computational chemistry, in vitro pharmacokinetics and protein production. These contracts cover most of Evotec's integrated discovery offering. In September 2015, the collaboration was extended for three years, and in August 2018 for another five years. With access to these resources, CHDI has all the tools in place to rapidly discover novel drugs against Huntington’s disease targets and further optimise them to the point of clinical development.
About Huntington’s disease
Huntington’s disease is a familial disease caused by a mutation in the huntingtin gene. Each child of a parent with the mutation in the huntingtin gene has a 50-50 chance of inheriting the mutation. As a result of carrying the mutation, an individual's brain cells fail and die leading to cognitive and physical impairments that, over the course of the disease, significantly impair the individual's quality of life and ultimately cause death. Symptoms of Huntington’s disease, which generally develop in midlife and become progressively more debilitating as time passes, can also develop in infancy or old age. Once overt symptoms start, patients live for about 15 to 20 years. One person in 10,000 is believed to carry a mutation in the huntingtin gene. There is currently no way to delay the onset of symptoms or slow the progression of Huntington’s disease.
C4X Discovery - Various indications
In September 2016, Evotec announced a multi-target collaboration with C4X Discovery Holdings plc ("C4XD"). The new agreement builds on the successful research collaboration with C4XD announced in January 2015 and will see C4XD and Evotec work together to develop new small molecule drugs across a range of targets, therapeutic areas and stages of development, with the initial programmes targeted towards the treatment of cancer and autoimmune diseases.
The new long-term strategic alliance will be a rolling multi-target programme with a minimum of three parallel drug discovery projects active at any point in time. As part of the agreement, Evotec will apply its extensive assay and screening technologies, laboratory scientists and medicinal chemistry know-how to selected C4XD programmes, in return for funding to partially cover operational costs, milestones dependent on developmental success and a share of potential future royalties.
Each programme will run until the point of Potential Development Candidate ("PDC") nomination, after which C4XD, which retains all IP, will have the right to out-license successful projects to the pharma industry or proceed itself to clinical studies on a case-by-case basis, as per its existing model.
Ferring - Reproductive medicine & Women`s health
In October 2018, Evotec and Ferring Pharmaceuticals (“Ferring”) announced a strategic research alliance to discover and develop new small molecule therapies to treat patients living with fertility and gynaecological conditions.
Evotec will apply its drug discovery platform to design novel, safe and efficacious treatments in partnership with Ferring. The multi-target, multi-year collaboration aims to deliver small molecule pre-clinical development (“PDC”) and investigational new drug (“IND”) ready candidates. As part of the alliance, Evotec is eligible for undisclosed research funding and milestones.
Sanofi - "MSA"
In March 2015, Evotec announced that a definitive agreement for a major multi-component strategic alliance over the next five years has been signed with Sanofi.
One major pillar of this agreement is the Master Service Agreement ("MSA"), where Evotec provide a broad range of long-term drug discovery services to Sanofi. Services can range from small, stand-alone studies up to more integrated packages.
This strategic outsourcing agreement is centred on the core small-molecule discovery platforms in Toulouse for the period of the contract over the next five years. In addition, Evotec will assume management of Sanofi's global screening compound library.
Takeda - various indications
In September 2019, Evotec SE announced a strategic, multi-year drug discovery collaboration with Takeda Pharmaceutical Company Limited (“Takeda”). Under the collaboration, the parties aim to establish at least five drug discovery programmes with the goal of Evotec delivering clinical candidates for Takeda to pursue into clinical development.
The collaboration combines Evotec’s ability to effectively drive fully integrated drug discovery programmes with Takeda’s strategic insights into transformative therapeutic approaches in Takeda’s four core therapeutic areas: Oncology, Gastroenterology, Neuroscience and Rare Diseases, as well as Takeda’s development and commercialisation expertise. Evotec will leverage its industry-leading discovery platform to validate therapeutic hypotheses and advance small molecule programmes with Takeda having options to assume responsibility at lead series and upon Evotec delivering a pre-clinical candidate.
Under the terms of the collaboration, Takeda will pay Evotec a one-time, upfront fee to access its platforms. Additionally, Evotec is eligible to receive pre-clinical, clinical, and commercial milestones that can total in excess of $ 170 m per programme as well as tiered royalties on future sales.
UCB - Various indications
In July 2011, Evotec and UCB entered into a three year integrated drug discovery collaboration to identify small molecule modulators of priority biological targets, selected by UCB, involved in CNS disorders.
As part of the collaboration, Evotec will apply its integrated drug discovery expertise and technologies to identify interesting small molecules against the selected targets. The molecules will be further optimised and progressed through lead optimisation to a pre-clinical candidate.
In October 2011, Evotec and UCB entered into a second multi-year, multi-target integrated drug discovery collaboration in the field of immunology. In October 2013, Evotec announced that the first two milestones were met in this immunology alliance with UCB. The milestones were achieved upon the progression of certain projects into hit-to-lead and into lead optimisation.
In October 2016 announced a collaboration with UCB to provide a broad range of in vitro pharmacology services.
Under the terms of the three-year agreement, Evotec will support UCB's in vitro pharmacology team in drug discovery projects across multiple target classes, particularly in the CNS space. Key activities will include assay development, compound profiling and mechanistic studies and will provide UCB with access to key Evotec expertise in the field of in vitro pharmacology and electrophysiology.