DMPK (Drug Metabolism and Pharmacokinetics) and ADME-Tox (Absorption, Distribution, Metabolism, Excretion and Toxicity)
Successful drug discovery requires a deep understanding of biological context coupled with knowledge and experience of the property space required to deliver safe, efficacious drugs; DMPK continues to be a key player in this success since the major sources of attrition – clinical efficacy and safety – are clearly linked to exposure in key tissues either on- or off-target.
Evotec and its wholly owned subsidiary Cyprotex offer a comprehensive and flexible range of in vitro and in vivo DMPK/ADME studies designed to cover the majority of activities in the hit-to-lead and lead optimisation phase through to candidate selection. We also offer in vitro metabolite profiling, structural elucidation and DDI (drug-drug interaction) studies for IND and NDA submissions during pre-clinical development and clinical stage projects.
There is realisation that evaluating toxicology earlier in a project reduces the risk of late-stage failure. As a consequence, human relevant cell-based models are being introduced in drug discovery to address this need. Cyprotex is leading the science in this field and have significant expertise in the latest techniques such as HCS, MEA and 3D cell-based models.
The scientific expertise and processes can be accessed as fee-for-services or as part of partially or fully integrated programmes. DMPK and ADME-Tox support will be provided to our partners in a variety of ways tailored to suit their specific project requirements.