In vitro ADME and PK Services
Our in vitro ADME and DMPK services include in vitro metabolism, in vitro permeability and transporters, solubility and physicochemical properties, in vitro protein binding and PK and bioanalysis.
Our listed services can be found below. Can't see the assay you need? Please contact us with your requirements.
In Vitro Metabolism
- Cytochrome P450 and UGT reaction phenotyping
- Cytochrome P450 induction
- Cytochrome P450 induction: relative induction score
- Cytochrome P450 inhibition
- Cytochrome P450 Ki
- Hepatocyte stability
- Low clearance HµREL co-culture assay
- Low clearance hepatocyte stability
- Hepatic uptake
- Metabolite profiling and identification
- Microsomal binding
- Microsomal stability
- Plasma stability
- PXR and AhR nuclear receptor activation
- S9 stability
- Time dependent inhibition (IC50 shift)
- Time dependent inhibition (kinact/Ki )
- Time dependent inhibition (single point)
- UGT inhibition
In Vitro Permeability and Transporters
- PAMPA
- Caco-2 permeability
- MDCK-MDR1 permeability
- P-gp substrate identification
- BCRP substrate identification
- Human SLC transporter substrate identification (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP)
- Human MRP transporter substrate identification
- Pre-clinical hepatic Oatp uptake transporter substrate identification (rat Oatp1b2, dog Oatp1b4 and Cynomolgus monkey Oatp1b1)
- P-gp inhibition
- BCRP inhibition
- Human SLC transporter inhibition (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP)
- BSEP and MRP inhibition
- Pre-clinical hepatic Oatp uptake transporter inhibition (rat Oatp1b2, dog Oatp1b4 and Cynomolgus monkey Oatp1b1)
Polymorphic and Non-CYP Mediated Metabolism
- Monoamine oxidase inhibition
- Monoamine oxidase reaction phenotyping
- Carboxylesterase inhibition
- Carboxylesterase reaction phenotyping
- Aldehyde oxidase reaction phenotyping
Protein Binding
- Brain tissue binding
- Plasma protein binding
- Whole blood binding
- Blood to plasma ratio
Bioanalysis
- Advanced bioanalytical method development, method transfer and method qualification
- Pharmacokinetics (PK) services
Prodrug Services
Can't see the assay you need? Please contact us with your requirements.