Physicochemical Profiling

Physicochemical Profiling

Poor physicochemical properties can present several challenges including:

  • Poor pharmacokinetics (e.g., reduced GI tract absorption leading to decreased oral bioavailability)
  • Reduced quality of the data from in vitro assays
  • Delays in the drug discovery and development process - extending the time of progression of drug candidates into the clinic and resulting in considerable additional expense
  • Reduced drug-like properties

Cyprotex offer a range of different physicochemical profiling screens including turbidimetric and thermodynamic solubility, chemical stability, pKa, and lipophilicity (log P and log D).

Our listed services can be found below. Can't see the assay you need? Please contact us  with your requirements.

Physicochemical Profiling Services

  • Turbidimetric Solubility
  • Thermodynamic Solubility
  • Chemical Stability and Non-Specific Binding Assessment
  • pKa and log P
  • log D Shake Flask
  • Early formulation assessment

Can't see the assay you need? Please contact us  with your requirements.

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