Evotec’s world-class ion channel platform combines industry-driven expertise with state-of-the-art instrumentation. In routine use are multiple setups for manual patch clamp studies and all of the most popular automated patch clamp instruments.
The automated patch clamps or FLIPRs can be used as entry points for high-throughput screenings (“HTS”). The manual and automated patch clamps enable on-going support of medicinal chemistry programmes progressing from HTS through hit expansion, hit-to-lead and lead optimisation but are also utilised for safety pharmacology.
We now offer brain and spinal cord slice electrophysiology to measure the effects of test substances or manipulation of CNS targets on synaptic function.
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