Expertise is provided in de novo X-ray crystallographic structure elucidation and repeat ligand complexes, facilitating novel structural information for guided, rational chemical design.
Routine and effective delivery of atomic structure information of bound ligands to drug targets, maximizes the efficiency of synthetic chemistry through structure-driven drug discovery. Comprehensive protein production expertise including E. coli, insect and mammalian expression systems is provided to meet our customer's needs. In addition, we have an experienced team in labeling studies such as N15 for NMR experiments and Seleno methionine for de novo crystal structure solution using multiple anomalous dispersive experiments.
Evotec also has a proven capability for characterization of fragment-binding by X-ray crystallography and structure-based medicinal chemistry optimization.