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Epigenetics Target Profiling®

Profile histone deacetylase (HDAC) inhibitors in cells and tissue:

  • Rapidly, reliably determining an HDAC inhibitor’s selectivity and affinity to an unrivaled number of native HDACs in a single experiment
  • Cellular profiling in native assays under conditions preserving the integrity of HDAC complexes

Epigenetics Target Profiling® is a hit-to-lead compatible assay that facilitates meaningful cellular selectivity profiling against nine class I / class II HDACs in a single cell line, and depicts a drug’s mode of action in the context of multi-protein complexes.

Evotec’s Cellular Target Profiling® platform is also applicable to native analysis of small molecules selecting for epigenetic targets other than HDACs; please contact us for further details at proteomics@evotec.com.