PhosphoScout®

PhosphoScout^® is an unbiased quantitative phosphoproteomics approach developed to comprehensively analyze in vivo signal transduction pathways and their response to drug treatment.

PhosphoScout^® helps annotate and quantify regulated phosphorylation sites in living cells, animal models and patient samples, delivering detailed insights into a compound’s cellular mode of action. Without requiring phospho-specific antibodies, it delivers global, unbiased analysis of the phosphoproteome by measuring the relative quantity of more than 15,000 phosphorylation sites in a single experiment.

Combine high-end quantitative mass spectrometry techniques with unrivaled software applications to facilitate:

• Mode of action analysis of targeted drugs
  System-wide modeling of signaling events enables investigating a drug’s influence on cellular phosphorylation patterns to significantly decrease development times in drug discovery
• Prediction of therapeutic outcome
  Investigating cross-talk effects on a drug’s efficiency and revealing potential mechanisms of cellular resistance. Overcoming the fundamental problem of non-responsiveness to a multitude of compounds or revealing additional therapeutic applications 
• Biomarker discovery
  Discovering predictive biomarkers that foretell the therapeutic outcome in a patient, which in turn allows personalized therapy approaches
• Target validation and identification of new drug targets
  Investigating a target’s downstream effect in relevant disease models such as knock-out or knock-in cells, or identifying new druggable proteins

For more information please contact us at proteomics@evotec.com