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KinAffinity®

Reveal the complete picture of a kinase inhibitor's interactions with the cellular kinome:

  • Simultaneously determining a kinase inhibitor’s selectivity and affinity to native kinase targets expressed in any given cell line or tissue
  • Rapidly, precisely and effectively profiling a kinase inhibitor against endogenously expressed, full-length proteins in the presence of cellular co-factors and native complex partners
  • Revealing interactions with protein kinases that are not detected by in vitro panel profiling

KinAffinity® is a hit-to-lead compatible approach to profile a compound against endogenously expressed, full-length proteins in the presence of cellular co-factors and native complex partners – a major advantage over traditional biochemical panel screening using only recombinantly expressed, purified proteins or protein domains.

For more information please contact us at proteomics@evotec.com