ADMET

Evotec offers a comprehensive range of high quality in vitro and in silico ADMET services. ADMET testing can help reduce the attrition rate within preclinical and clinical testing, through elimination of compounds with poor PK properties at an early stage. Assessing potential ADMET liabilities early on can also dramatically reduce the time required for lead optimisation.

Available in vitro assays include:

• Aqueous solubility
• PAMPA
• Caco-2 and MDCK-MDR1 permeability
• Protein binding
• Microsomal stability
• Hepatocytes stability
• Plasma stability
• hERG
• Cytrochrome P450 inhibition and induction
• Cellular cytotoxicity
• Bioanalysis

In silico models include hERG interaction, blood brain barrier penetration, human serum albumin binding, AMES...

For a complete list of assays, please contact us at info@evotec.com