Zebrafish Screening

Zebrafish have the potential to accelerate and de-risk the drug discovery and development process by reducing attrition rates and lowering the development cost of producing new drugs. Zebrafish are well-characterised model organisms and are used in the screening of potential drug candidates to provide invaluable in vivo safety and efficacy data from the earliest stages of drug discovery and throughout the development process.

With a significant genetic similarity to humans and the presence of many vital organs including heart, brain and liver, the larval zebrafish is highly suitable for screening potential drug candidates for efficacy and safety effects. Screening in zebrafish provides many advantages over other established in vivo models by allowing large numbers of compounds to be rapidly profiled using small amounts of compound.

Evotec provides a range of safety pharmacology and toxicity screens and also several zebrafish disease models that can be used to identify and evaluate potential new drug candidates:

Assays are typically run as 6-point concentration response requiring just single milligrams of compound

Disease models in development include: Parkinson’s Disease (LRRK2 overexpression) and skin pigmentation.

Evotec would also be happy to discuss your requirements for other disease models. For more information, please contact us at info@evotec.com